Systems Neuroscience Group
Molecular Neuroendocrinology
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Viviana Bumaschny
Adjunct Investigator, CONICET
Teaching Assistant, UBA
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In the Laboratory of Molecular Neuroendocrinology, we study the brain circuits that control appetite and glucose regulation. To achieve this, we use models of obese and diabetic mutant mice. Our research involves various fields such as neuroscience, neuroendocrinology, molecular biology, genetic engineering, and behavioral biology.
Members
Internship
FMED – UBA
Contact
Selected Publications
- Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice. Trotta M, Bello EP, Alsina R, Tavella MB, Ferrán JL, Rubinstein M, Bumaschny VF. Mol Metab, 2020 Jul, (37), 100985
- Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice. Alsina R, Trotta M, Bumaschny VF. Front Endocrinol (Lausanne), 2018, (9), 554
- Enhancer turnover and conserved regulatory function in vertebrate evolution. Domené S, Bumaschny VF, de Souza FS, Franchini LF, Nasif S, Low MJ, Rubinstein M. Philos Trans R Soc Lond B Biol Sci, 2013 Dec 19, 1632 (368), 20130027
- Obesity-programmed mice are rescued by early genetic intervention. Bumaschny VF, Yamashita M, Casas-Cordero R, Otero-Corchón V, de Souza FS, Rubinstein M, Low MJ. J Clin Invest, 2012 Nov, 11 (122), 4203-12
- Establishment of an in vitro estrogen-dependent mouse mammary tumor model: a new tool to understand estrogen responsiveness and development of tamoxifen resistance in the context of stromal-epithelial interactions. Pontiggia O, Rodriguez V, Fabris V, Raffo D, Bumaschny V, Fiszman G, de Kier Joffé EB, Simian M. Breast Cancer Res Treat, 2009 Jul, 2 (116), 247-55
- Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene. Santangelo AM, de Souza FS, Franchini LF, Bumaschny VF, Low MJ, Rubinstein M. PLoS Genet, 2007 Oct, 10 (3), 1813-26
- Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence. Bumaschny VF, de Souza FS, López Leal RA, Santangelo AM, Baetscher M, Levi DH, Low MJ, Rubinstein M. Mol Endocrinol, 2007 Nov, 11 (21), 2738-49
- Subfunctionalization of expression and peptide domains following the ancient duplication of the proopiomelanocortin gene in teleost fishes. de Souza FS, Bumaschny VF, Low MJ, Rubinstein M. Mol Biol Evol, 2005 Dec, 12 (22), 2417-27
- Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting. de Souza FS, Santangelo AM, Bumaschny V, Avale ME, Smart JL, Low MJ, Rubinstein M. Mol Cell Biol, 2005 Apr, 8 (25), 3076-86
- Herpes simplex virus thymidine kinase/ganciclovir system in multicellular tumor spheroids. Finocchiaro LM, Bumaschny VF, Karara AL, Fiszman GL, Casais CC, Glikin GC. Cancer Gene Ther, 2004 May, 5 (11), 333-45