
Laboratory of Renal Physiology
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Claudia M Silberstein
Researcher, UBA
Teaching Assistant, UBA
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Our research group studies mechanisms of protection and prevention of renal damage caused by Shiga toxin 2 (Stx2), responsible for Hemolytic Uremic Syndrome. We also investigate factors involved in the process of regeneration and repair of renal epithelia.


Members

Teaching Assistant
UBA
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Doctoral Fellow
Conicet
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Doctoral Fellow
Foncyt
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Selected Publications
- Ovariectomy and high salt increase blood pressure and alter sodium transport proteins in peripheral blood mononuclear cells of adult Wistar rats. Vlachovsky SG, Di Ciano LA, Oddo EM, Azurmendi PJ, Goette NP, Arrizurieta EE, Silberstein C, Ibarra FR. Exp Physiol, 2021 Oct, 10 (106), 2107-2123
- Eliglustat prevents Shiga toxin 2 cytotoxic effects in human renal tubular epithelial cells. Sánchez DS, Fischer Sigel LK, Balestracci A, Ibarra C, Amaral MM, Silberstein C. Pediatr Res, 2022 Apr, 5 (91), 1121-1129
- Estradiol stimulates cell proliferation via classic estrogen receptor-alpha and G protein-coupled estrogen receptor-1 in human renal tubular epithelial cell primary cultures. Sánchez DS, Fischer Sigel LK, Azurmendi PJ, Vlachovsky SG, Oddo EM, Armando I, Ibarra FR, Silberstein C. Biochem Biophys Res Commun, 2019 Apr 30, 2 (512), 170-175
- Effects of shiga toxin 2 on cellular regeneration mechanisms in primary and three-dimensional cultures of human renal tubular epithelial cells. Márquez LB, Araoz A, Repetto HA, Ibarra FR, Silberstein C. Microb Pathog, 2016 Oct, (99), 87-94
- Effects of Escherichia coli subtilase cytotoxin and Shiga toxin 2 on primary cultures of human renal tubular epithelial cells. Márquez LB, Velázquez N, Repetto HA, Paton AW, Paton JC, Ibarra C, Silberstein C. PLoS One, 2014, 1 (9), e87022
- Intraperitoneal administration of Shiga toxin 2 induced neuronal alterations and reduced the expression levels of aquaporin 1 and aquaporin 4 in rat brain. Lucero MS, Mirarchi F, Goldstein J, Silberstein C. Microb Pathog, 2012 Aug, 2 (53), 87-94
- Epithelial cells activate plasmacytoid dendritic cells improving their anti-HIV activity. Rodriguez Rodrigues C, Cabrini M, Remes Lenicov F, Sabatté J, Ceballos A, Jancic C, Raiden S, Ostrowski M, Silberstein C, Geffner J. PLoS One, 2011, 12 (6), e28709
- A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2. Silberstein C, Lucero MS, Zotta E, Copeland DP, Lingyun L, Repetto HA, Ibarra C. Pediatr Res, 2011 May, 5 Pt 1 (69), 390-4
- Clostridium perfringens epsilon toxin is cytotoxic for human renal tubular epithelial cells. Fernandez Miyakawa ME, Zabal O, Silberstein C. Hum Exp Toxicol, 2011 Apr, 4 (30), 275-82
- UT-A expression in pars recta from a rat model of chronic renal failure. Zotta E, Ochoa F, Tironi Farinati C, Damiano A, Silberstein C, Levy Yeyati N, Ibarra C. J Nephrol, 2008 Nov-Dec, 6 (21), 947-58