The Laboratory of Neuronal Pathophysiology at IFIBIO is engaged in research lines that integrate multidisciplinary approaches, including behavioral, pharmacological, biochemical, and molecular studies, to understand the pathogenesis of neurodegenerative diseases. This understanding is crucial for developing new and more effective therapies. Specifically, our focus is on TDP-43 proteinopathies, including Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and other diseases related to TDP-43 protein alterations. We utilize cellular and animal models, including transgenic mice, to investigate these conditions.