
Neurobiology of the Retina
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Paula Faillace
Independent Researcher, CONICET
Teaching Assistant, UBA
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The zebrafish is a vertebrate that has the ability to regenerate organs and tissues throughout its adult life. Unlike mammals, this fish can repair different structures of the nervous system. In our laboratory, we study the regeneration of the neural retina after inducing different types of injuries that lead to visual function recovery, and we investigate the mechanisms involved in this regeneration. This includes cell proliferation, death, and differentiation, as well as factors (intercellular, hormonal, and epigenetic signaling mechanisms) involved in regulating angiogenesis, neurogenesis, and gliogenesis that lead to tissue repair and vision recovery.



Doctoral Fellow
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Doctoral Fellow
Conicet
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- Evaluation of drug seeking behavior on nicotine conditioned place preference in zebrafish. Rocco L, Pisera-Fuster A, Faillace MP, Bernabeu R. Prog Neuropsychopharmacol Biol Psychiatry, 2022 Dec 20, (119), 110593
- Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish. Faillace MP, Bernabeu RO. Curr Neuropharmacol, 2022 Mar 4, 3 (20), 510-523
- Extracellular ATP hydrolysis in Caco-2 human intestinal cell line. Schachter J, Alvarez CL, Bazzi Z, Faillace MP, Corradi G, Hattab C, Rinaldi DE, Gonzalez-Lebrero R, Molineris MP, Sévigny J, Ostuni MA, Schwarzbaum PJ. Biochim Biophys Acta Biomembr, 2021 Oct 1, 10 (1863), 183679
- P2X7 and A(2A) receptor endogenous activation protects against neuronal death caused by CoCl(2) -induced photoreceptor toxicity in the zebrafish retina. Medrano MP, Pisera-Fuster A, Bernabeu RO, Faillace MP. J Comp Neurol, 2020 Aug, 12 (528), 2000-2020
- Pre-Exposure to Nicotine with Nocturnal Abstinence Induces Epigenetic Changes that Potentiate Nicotine Preference. Pisera-Fuster A, Faillace MP, Bernabeu R. Mol Neurobiol, 2020 Apr, 4 (57), 1828-1846
- Sensitization-dependent nicotine place preference in the adult zebrafish. Pisera-Fuster A, Rocco L, Faillace MP, Bernabeu R. Prog Neuropsychopharmacol Biol Psychiatry, 2019 Jun 8, (92), 457-469
- Purinergic signaling in the retina: From development to disease. Ventura ALM, Dos Santos-Rodrigues A, Mitchell CH, Faillace MP. Brain Res Bull, 2019 Sep, (151), 92-108
- Characterization of proliferative, glial and angiogenic responses after a CoCl(2) -induced injury of photoreceptor cells in the adult zebrafish retina. Medrano MP, Pisera Fuster A, Sanchis PA, Paez N, Bernabeu RO, Faillace MP. Eur J Neurosci, 2018 Nov, 9 (48), 3019-3042
- Evaluation of the rewarding properties of nicotine and caffeine by implementation of a five-choice conditioned place preference task in zebrafish. Faillace MP, Pisera-Fuster A, Bernabeu R. Prog Neuropsychopharmacol Biol Psychiatry, 2018 Jun 8, Pt A (84), 160-172
- Injury-induced purinergic signalling molecules upregulate pluripotency gene expression and mitotic activity of progenitor cells in the zebrafish retina. Medrano MP, Bejarano CA, Battista AG, Venera GD, Bernabeu RO, Faillace MP. Purinergic Signal, 2017 Dec, 4 (13), 443-465
- Short- and long-term effects of nicotine and the histone deacetylase inhibitor phenylbutyrate on novel object recognition in zebrafish. Faillace MP, Pisera-Fuster A, Medrano MP, Bejarano AC, Bernabeu RO. Psychopharmacology (Berl), 2017 Mar, 6 (234), 943-955
- Effects of combined nicotine and fluoxetine treatment on adult hippocampal neurogenesis and conditioned place preference. Faillace MP, Zwiller J, Bernabeu RO. Neuroscience, 2015 Aug 6, (300), 104-15
- Behavioral and molecular analysis of nicotine-conditioned place preference in zebrafish. Kedikian X, Faillace MP, Bernabeu R. PLoS One, 2013, 7 (8), e69453
- Purinergic signals regulate daily S-phase cell activity in the ciliary marginal zone of the zebrafish retina. Ricatti MJ, Battista AG, Zorrilla Zubilete M, Faillace MP. J Biol Rhythms, 2011 Apr, 2 (26), 107-17
- Extracellular ADP regulates lesion-induced in vivo cell proliferation and death in the zebrafish retina. Battista AG, Ricatti MJ, Pafundo DE, Gautier MA, Faillace MP. J Neurochem, 2009 Oct, 2 (111), 600-13