
Systems Neuroscience Group
Physiology of Animal Behavior
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Juan Belforte
Independent Investigator, CONICET
Teaching Assistant, UBA
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The general goal of our research line is to understand the role of postnatal maturation of cortico-limbic inhibitory circuits in relation to the development of psychiatric disorders. Our experimental approach employs various tools, including the use of genetically modified mice with site-specific modifications, manipulation of neuronal activity using optogenetics and DREADDs (Designer Receptors Exclusively Activated by Designer Drugs), in vivo electrophysiological recording techniques, and an extensive battery of behavioral tasks.


Members

Assistant Investigator
Conicet
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Teaching Assistant
UBA
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Doctoral fellow
Conicet
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Doctoral fellow
Foncyt
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Doctoral fellow
Conicet
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Selected Publications
- Striatal Cholinergic Interneurons Are Required for Contending Strategy Selection While Solving Spatial Navigation Problems. Beccaria JP, Pretell Annan CA, Keifman E, Murer MG, Belforte JE. J Neurosci, 2022 Feb 16, 7 (42), 1303-1315
- Early NMDA Receptor Ablation in Interneurons Causes an Activity-Dependent E/I Imbalance in vivo in Prefrontal Cortex Pyramidal Neurons of a Mouse Model Useful for the Study of Schizophrenia. Pafundo DE, Pretell Annan CA, Fulginiti NM, Belforte JE. Schizophr Bull, 2021 Aug 21, 5 (47), 1300-1309
- Interneuron NMDA Receptor Ablation Induces Hippocampus-Prefrontal Cortex Functional Hypoconnectivity after Adolescence in a Mouse Model of Schizophrenia. Alvarez RJ, Pafundo DE, Zold CL, Belforte JE. J Neurosci, 2020 Apr 15, 16 (40), 3304-3317
- Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons. Martos YV, Braz BY, Beccaria JP, Murer MG, Belforte JE. J Neurosci, 2017 Mar 15, 11 (37), 2849-2858
- Altered Corticostriatal Connectivity and Exploration/Exploitation Imbalance Emerge as Intermediate Phenotypes for a Neonatal Dopamine Dysfunction. Braz BY, Galiñanes GL, Taravini IR, Belforte JE, Murer MG. Neuropsychopharmacology, 2015 Oct, 11 (40), 2576-87
- Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation. Jinde S, Zsiros V, Jiang Z, Nakao K, Pickel J, Kohno K, Belforte JE, Nakazawa K. Neuron, 2012 Dec 20, 6 (76), 1189-200
- Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Belforte JE, Zsiros V, Sklar ER, Jiang Z, Yu G, Li Y, Quinlan EM, Nakazawa K. Nat Neurosci, 2010 Jan, 1 (13), 76-83